Monthly Archives: March 2015

Sensing Cancer

Georgia Tech is pushing the boundaries of sensor applications with this opportunity (in its very early stages):

What if we could sense cancer?
DNA Sensor Detects Cancer

Prof. Amir Saheb, a GT Ph.D. alumni and Dr. Ehsan Najafabadi, who graduated last summer from Prof. Bernard Kippelen’s lab at GT, have collaborated to commercialize aspects of Prof. Saheb’s graduate and professorial research. This DNA chip has 16 sensors capable of detecting up to 16 types of cancer in one pass using novel electrochemical ‘fingerprints.’ Cancer cells have specific methylated gene patterns. These epigenetic traits can be measured by this sensor with extremely high specificity.

This means that in diagnostic tests, such as the PSA, (which looks for prostate cancer) false positives could potentially be reduced by an order of magnitude.

This product, if clinically deployed, will require regulatory approval. Their mentor, Tim Murray, CEO of ViveBio has helped guide the team toward their first diagnostic indication. For more information, please email, ehsan.najafabadi@gmail.com.

Smart Watches

So we are about to find out whether I need to trade in my Rolex and get a Smart Watch. This space is worth watching.

Pebble got to the Smart Watch Space first. Amazing progress:

“What is undeniably true is that Pebble has sold more than one million watches in three years, and six days into a 30-day Kickstarter campaign, has sold another $14 million worth. With that, the company has re-claimed the title (it first took with the original Pebble) as the most funded Kickstarter project ever.”

So my personal history is that start-up companies are very, very lucky to get 3-5 investors. They have 68,000! They are the leader of a new wave of start-ups that are fed by places like Kickstarter.com.

The story is told one way in this amazing depiction of Pebble and its founder:

Pebble and Its Founder

So another way to ask the question is this: are watches and wearables about to merge? As I said in a post last year (http://johncreid.com/2014/10/fitbit/ ), FITBIT owns the 3.3 million wearables market but now we see Pebble selling 1 million watches, and Apple entering very soon. So which is it? A watch? A wearable? or Both?

This article in WIRED (today’s edition!) speaks to this issue:

WIRED ARTICLE on Pebble

So Pebble is going hard over on this question to …. it’s a watch, stupid! And therefore it’s all about time – past (what you did), present (what’s happening now, like rain or traffic), and future (like calendar stuff). They have decided to call their new watch “Pebble Time” – and make the user interface manageable by organizing the massive data available by – – – time! They are being maniacal about it – taking their 6,000+ developers and moving the user from “apps” to time – the apps operate in the background but only appear to the user based on time. So if you want to know the game score from Friday night, scroll back to Friday night and poof, there it is. Weather this afternoon? Scroll to this afternoon. Brilliant!

And apparently they solved some really tricky issues. They preserved battery life as they added features. Charge lasts 7 days. They reserved a low price point – unlike Apple, they are less than $200 (Apple is $349+).

Its not that they are abandoning wearables – not at all. Its just that they are leaving this mainly to developers who can build around the Pebbles Operating System.

Great article about the Smart Watch space – and the upcoming launch of the Apple Watch:

Pebble Article

MIT Collaborative Initiatives New Models Participants (I attended in 2013, 2014, and 2015):

Past Participants

John Abele Boston Scientific Corporation Joan AbrahamsonPhD President, Jefferson Institute Noubar AfeyanPhD Founder, Managing Partner and CEO, Flagship Ventures Esko Aho President, Sitra, Finnish Innovation Fund; Former Prime Minister of Finland Lars Albright CEO, SessionM Warner AndersonCol Director, International Health, OASK(HA)/TMA Amanda Arnold Senior Policy Advisor, MIT Washington Office Norm Augustine Former CEO and Chairman, Lockheed Martin Corp Dennis A. AusielloMD Jackson Distinguished Professor of Clinical Medicine and Director Emeritus, MD/PhD Program, Harvard Medical School; Chairman Emeritus, Department of Medicine and Director, Center for Assessment Technology and Continuous Health (CATCH), Massachusett General Hospital Charles D. Baker President and CEO, Harvard Pilgrim Health Robert BancoMD Chief of Spine Center, NEBH Gillian BarclayDDS, DRPH VP, Aetna Foundation James G. BarlowPhD, FRSA, FRSM Professor, Tanaka Business School, Imperial College, London Alan I BaronEsq Seyfarth Shaw, LLP Jarrett Tomas Barrios President, BC/BS of Massachusetts Foundation Elmer Bartels Commissioner MA Rehabilitation Commission Sonja BattenMD Defense Centers of Excellence for PH and TBI Rebecca Bavinger Bloomberg Philanthropies John Becker Tricare Management Activity Herb BensonMD Founding President, Mind/body Medical Institute, MGH; Professor of Medicine, Harvard Medical School Edward J. Benz, Jr.MD President & CEO, Dana Farber Cancer Institute Harris A. Berman, MDMD Dean, Public Health, Tufts University; Fmr CEO Tufts Health Plan Dimitris BertsimasPhD Professor, MIT Sloan School of Management Donald M. BerwickMD, MPP, FRCP President and CEO, Institute for Healthcare Improvement Emilio Bizzi Institute Professor in the Brain Sciences and Human Behavior, MIT Gerald W. Blakeley, Jr. President, Blakeley Investment Company Michael R. BloombergThe Honorable Fmr Mayor of New York City David BlumenthalMD, MPP, FRCP Director, Institute for Health Policy, Professor of Medicine and Professor of Health Care Policy, Harvard Medical School Susan J. BlumenthalMD, MPA CSP Senior Advisor for Health and Medicine; Fmr U.D Assistant Surgeon General; Fmr Deputy Assistant Secretary for Women’s Health, U.S. Department of Health and Human Services Blenda Bochette Business Strategy, Steelcase Corporation Anita M. BoddiePhD, FACN, RD Senior Director, Global Government and Public Affairs, McDonald’s Corporation Stephen Booma EVP, BC/BS of Massachusetts Michael BoquardCAPT Coast Guard Health, Safety and Work-life Directorate H. Kent Bowen Professor, Harvard Business School Jon BowersoxMD Ethicon Eno-Surgery Bruce Bradley General Motors Ronald Brownstein Editorial Director, National Journal Group Martin Brunswick Product Manager, InterSystems Corp. HealthShare Active Analytics AJ Brustein Innovation Accelerator Director, The Coca-Cola Company Nonnie Burnes Insurance Commissioner, State of Massachusetts Doug Busch Strategy CTO, Intel Neil S. CalmanMD President & CEO, institute for Urban Family Health Kjell Carlsson RA, Institute for Strategy and Competitiveness George W. Carmany III Brown Brothers Harriman James CarrollCol Air Force Deputy Assistant Surgeon General, Modernization Larry Casaline Associate Professor Department of Health Sciences, University of Chicago Steve Case Chairman, Case Foundation Martha CaseyEsq. Partner, O’Neill, Athy & Casey S. Ward CasscellsMD, The Honorable Fmr Assistant Secretary of Defense for Health Affairs, Fmr VP Biotechnology Health Science Center, University of Texas; Founder, Institute of Nanotechnology John Castellani President & CEO, Pharma Mehmet Erkan CeyhanPhD Operation Managment Project Manager Surgical Services, Lahey Hospital & Medical Center Reginald A. Chambers White House Fellow Eugene Y. ChanMD, PhD Founder, DNA Medicine Institute; U.S. Genomics Lauren Choi Principal and General Counsel, CCK Global Parnters, LLC Benjamin K. ChuMD Regional President, Southern California, Kaiser Foundation Health Plan and Hospital Conrad A. Clyburn US Army Telemedicine and Advanced Research Center, Georgetown University Medical School Kathy G. Cochran Senior Advisor, Boston Consulting Group Lawrence H. CohnMD Partners Healthcare; Professor of Cardiac Surgery, Physician Director, Medical Technology Herbert F. Collins CEO Collins & Company, LLC Michael Conard Project Director, Associate Professor of Architecture Justin Cook Strategic Design Lead, SITRA [Finnish Innovation Fund] Denis A. CorteseMD Arizona State University, Former President and CEO Mayo Clinic Toby CosgroveMD CEO & President, Cleveland Clinic Elaine Bowers Coventry Group Director, Global Customer Marketing, The Coca-Cola Company Karen CozeanCol Army Medical Specialty Corps Thomas R. CullisonRear Admiral U.S. navy Medical Corps, Deputy Surgeon General, Vice Chief, Bureau of Medicine and Surgery Lynda C. DavisPhD Fmr, DOD Deputy Undersecretary, Military Community & Family Policy Heather DawesPhD Vice President, Science, Fidelity Foundation David C. DeitzMD, PhD Vice President, National Medical Director, Liberty Mutual Group Susan Dentzer Editor-In-Chief, Health Affairs; Health Correspondent, PBS News Hour with Jim Lehrer Lauren Dewey-PlattPhD Executive Director, Scholars in Clinical Science Program, Harvard Medical School Michael DinneenMD, PhD Direcotr Office of Strategy Management, Office of the Assistant Secretary of Defense for Health Affairs Peter Doelger Entrepreneur R. Bruce DonoffDMD, MD Dean, Harvard School of Dental Medicine Kevin DorranceCDR Medical Home Director, National Naval Medical Center Frank Douglas Director, MIT Center for Biomedical Innovation Andrew Dreyfus Executive Vice President for Health Care Services, BC/BS of MA Thelma Duggin AnBryce Foundation Jeri Eckhart-Queenan Partner, The Bridgespan Group Elazer Edelman, MD, PhD Thomas D. and Virginia W. Cabot Professor of Health Sciences and Technology at MIT; Professor of Medicine at Harvard Medical School; Senior Attending Physician in the coronary care unit at Brigham and Women’s Hospital, Boston David EisenbergMD Director, Oscher Institute; Director, Integrated Medicine harvard Medical School Ezekial EmanuelMD Special Advisor for Health Policy Office of Management & Budget Executive Office of the President, USA Ellen Embrey Fmr Acting PDASD, Health Affairs Alfred Engelberg Trustee, The Engelberg Foundation Richard ErdtmannMD Institute of Medicine Terry J. Fadem Director, Office of Corporate Alliances, University of Pennsylvania Karen Wolk FeinsteinPhD President and CEO, Jewish Healthcare Foundation; CEO Pittsurgh Regional Health Initiative Brian Fiore Health Affairs Human Capital Program Manager Naomi FiredPhD Chief Innovation Officer, InnovationAcceleration Program, Boston Children’s Hospital Georgina Campbell FlatterMS, MEng Director, Executive Programs & MIT Regional Entrepreneurship Acceleration Program (REAP), Martin Trust Center for MIT Entrepreneurship William H. FristMD Frederick H. Schultz Professor of International Economic Policy at Princeton University’s Woodrow Wilson School of Public and International Affairs; fmr Majority Leader of the US Senate Donald GaglianoCOL DOD Vision Center of Excellence John I. GallinMD Director, NIH Clinical Center Christopher Geary COO, Asianet Group; CEO, APAC of Talent Works International; CIO, YTS Investments Newt GingrichPhD CEO, Gingrich Group; Founder, Center for Health Transformation Marc C. GinsbergThe Honorable Fmr Presidential Advisor and US Ambassador John GlaserPhD Vice President and CIO, Partners Healthcare System, Inc. Jeffrey GlassrothMD Vice Dean, Academic and Clinical Affairs, Tufts University School of Medicine Wiljeana J. GloverPhD, MS Assistant Professor, Technology, Operations, and Information Management Division, Babson College Dan Goldin Chairman and CEO, The Intellisis Group Arthur L. Goldstein Fmr CEO Ionics; Chairman, Governance Committee, State Street Corporation R. Gilbert GonzalezMD, PhD Director, Neuroradiology, Massachusetts General Hospital Elder GrangerMG Deputy Director, TMA Charles Bruce GreenMAJGEN Air Force Surgeon General Paul S. Grogan President & CEO, The Boston Foundation Donald Gross Senior Advisor, Albright-Stonebridge Group Gil Grosvenor Chairman, National Geographic Foundation Jonathan GruberPhD Professor of Economics, MIT; Director, Health Care Program, National Bureau of Economic Research; Co-Editor, Journal of Public Economics Bob Hale Under Secretary of Defense, Comptroller Olaf HaugenCAPT Navy Bureau of Medicine Kerry Healey Former. Lt. Governor Massachusetts Oliver C. HenkerR. Chief Government Relations Officer, Office of Government Relations, Cleveland Clinic Susan HockfieldPhD President MIT Patricia D. HorohoMajor General US Army Commander, Western Regional Medical Command; Commander, Madigan Army Medical Center, FT Lewis, WA; Chief, Army Nurse Corp; Manager, TRICARE Puget Sound, WA Charles Hume US Department of Veterans Affairs Christine S. HunterRear Adm Incoming Deputy Director for TRICARE Management Activity Alice Jacobs Chairman & CEO, Intelligent Medical Devices Paula A. JohnsonMD, MPH Executive Director, Connors Center for Women’s Health and Gender Biology; Chief of the Division of Women’s Health at Brigham and Women’s Hospital; Harvard Medical School Daniel W. JonesMD President American Heart Association; Vice Chancellor for Health Affairs, Dean School of Medicine, Herbert G. Langford Professor of Medicine, University of Mississippi Medical Center Stephen L. JonesMD Principal Deputy, Assistant Secretary of Defense Health Affairs), Office of the Secretary of Defense Janice Joyner Special Assistant to Secretary Togo West Steve Kadish Director of the Division of Social Medicine and Health Inequalities, Brigham & Women’s Hospital David Kildee Prof. Staff Member, Commission on Armerd Svcs., US House of Representatives Michael KilpatrickMD Director, MHS Strategic Communications William A. Knaus Evelyn Troup Hobson Professor and Chairman Department of Public Health Sciences, University of Virginia School of Medicine Akhila KosarajuMD Health Affairs Ted Krueger Associate Dean Architecture, Rensselaer Christian J. KryderM.D. Harvard School of Design, Center for Environment & Technology John KuglerMD, COL Chief Medical Officer, DOD, TMA Thom KurmelCOL Chief of Staff, Health Affairs, Personnel and Readiness, United States Department of Defense Michael J. KussmanMD, The Honorable Under Secretary for Health for the Veterans Health Administration, Brigadier General U.S. Army ret. Robert LangerScD Institute Professor, MIT Larry LaughlinMD Dean, USU School of Medicine Thomas H. LeeMD, MSc Network President and CEO, Partners HealthCare System/Partners HealthCare Community, Inc. LaSalle LeffallMD President’s Cancer Advisory Board; Howard University Gail LeseM.D. Chief Investment Officer, Mugar Enterprises Frank Levy Rose Professor of Urban Economics, Department of Urban Studies and Planning, M.I.T. Michelle Leyden Li Director of Business Development, Intel Donald A.B. LindbergMD Director, National Library of Medicine, NIH Harvery LodishPhD Founding Member Whitehead Institute, Professor of Biology, MIT Michael Love President & CEO, Steelcase Design Partnership John M. MateczunRADM Commander, Joint Task Force, National Capital Region Medical; Member Task Force on the Future of the Military Health System Dave McGinnis Principal Deputy ASD for Reserve Affairs Thomas McGinnisRADM Chief, Pharmaceutical Operations Directorate Christopher J. McKown President, Health Dialog Services Corporation Joseph C. McNay Chairman, Chief Investment Officer & Managing Principal, Essex Investment Management Group, LLC William F. McSweeney Former President Occidental International Group Dana Mead Chairman, MIT Al Middleton Michael MittelmanMD, RADM U.S. Navy James J. MonganMD President and CEO, Partners HealthCare System; Chair, Commonwealth Fund Commission on a High Performance Health System Donald E. MorelPhD CEO, West Pharmaceutical Services Tommy Morris Office of Deputy Assistant Secretary of Defense for Force Health Protection & Readiness Programs Joel Moses Institute Professor, Professor of Computer Science and Engineering and Engineering Systems; Acting Director, Center for Technology, Policy and Industrial Development MIT Aaron Moskowitz Executive Editor, Biomedical Research & Education Foundation Mohsen Mostafavi Dean, Harvard Graduate School of Design Patricia A. Murphy US Department of State Campbell MurrayMD Managing Director, Novartis Bioventure Fund Matt NathanRADM Cammander, Navy Medicine National Captial Area Deb Nightingale MIT Dept of Aeronautics & Astonautics and Engineering Systems Don NoaCOL MHS Acting DASD FHP&R Dave O’Leary EVP, HR State Street Corporation Bob OpsutMD Health Affiars HB&FP John ParkerMD, GEN ret SAIC James B. PeakeMD, The Honorable Lt. General U.S. Army (ret), Former Secretary of Veterans Afairs Dan Peterson Vice President Industry & Government Affairs, Cook Group Incorporated Sally PhillipsMD AHRQ Michael PorterMBA, PhD University Professor, Director Institute for Strategy and Competitiveness, Harvard Business School Franklin D. Raines Vice Chairman of the Board, Revolution Health Group, LLc Uwe E. Reinhardt James Madison Professor of Political Economy
Professor of Economics and Public Affairs, Woodrow Wilson School of Public & International Affairs, Princeton University Darrel Rhea CEO, Cheskin Jeannine M. Rivet President & CEO, Optum; EVP and Fmr CEO, United Health Group Leslie Robinson Representative of United Health Foundation Mary Ann Rockey Program Executive Officer/Deputy Chief Information Officer James Roosevelt Jr. President and Chief Executive Officer, Tufts Health Plan William L. RoperMD, MPH CEO University of North Carolina Health Care System, Dean UNC School of Medicine and Vice Chancellor Medical Affairs Stuart A. RosenbergM.D. President & CEO harvard Medical Faculty Physicians at Beth Israel Deaconess Medical Center James RoudebushLt. Gen USAF Surgeon General Tod RussellCOL Air Force Deputy Assistant Surgeon General, Modernization Jaquelne RychnovskyCAPT Senator Daniel K. Inouye William A. Sahlman Dimitri V. D’Arbeloff – Class of 1955 Professsor of Business Administration, Senior Associate Dean for External Relations, Harvard Business School David Schmittlein John C. Head III Dean, MIT Sloan School of Management Daniel L. SchodekProf Dept. of Architecture, Harvard Design School Stephen C. SchoenbaumMD Executive Vice President, Commonwealth Fund; Executive Director, The Commonwealth Fund Commission on a High Performance Health System Patricia Q. Schoeni Executive Director, National Coalition on Health Care Eric B. SchoomakerLt. General USArmy Surgeon General Stephen R. SeilerJD Managing Partner, Windgate Partners David Seligman CEO, Best Doctors Gary SetnikMD, FACEP Chairman, Dept. of Emergency Medicine, Mount Auburn Hospital James D. Shields President and CEO Draper Labs David SmithRADM DOD Joint Staff Surgeon Jack SmithMD MHS Acting DASD C&PP Steven Spear Professor, Harvard Business School Marco SteinbergMArch Director of Strategic Design, SITRA (Finnish Innovation Fund); former Associate Professor of Architecture, Harvard Graduate School of Design Vikas P. SuhatmeMD, PhD Professor of Medicine, Harvard Medical School; Chief, Renal Division, Beth Israel Deaconess Medical Center Louis W. SullivanMD, The Honorable Founder, President Emeritus, Morehouse School of Medicine; Former Secretary of Health & Human Services; Chairman, The National Health Museum Loree SuttonBG Center of Excellence James Tallon President, United Hospital Fund; Chairman, Commonwealth Fund Elizabeth TeisbergPhD Associate Professor, Darden Business School, University of Virginia Jeff Teitz Senator Edward Kennedy’s Office Samuel O. ThierMD Professor of Medicine and Health Care Policy Emeritus, Harvard Medical School Doug Thompson VP, Sentara Healthcare Nancy Tomich Institute of Federal Healthcare John UlloPhD Director of Research, Shlumberger-Doll Lawrence J. Vale Professor and Head, Department of Urban Studies and Planning, MacVicar Faculty Fellow, MIT Charles M. Vest President, National Academy of Engineering; President Emeritus, MIT Maureen Viall MHS Chief Human Captial Officer Natalya Vinokurova RA Institute for Strategy and Competitiveness Daniel WattendorfLT COL Air Force Deputy Assistant Surgeon General, Modernization Albert WaxmanPhD Senior Managing Member, Psilos Group Managers, LLC Rob Webb President, United Resource Networks Anthony Welters EVP, President, Public & Senior Markets Group, UnitedHealth Group John E. WennbergMD Director, Center for the Evaluative Clinical Sciences, Dartmouth Medical School Togo WestThe Honorable Chairman, TLI Leadership Group Deborah WheelingMG Deputy Surgeon General for the Army National Guard Andy WiesenthalMD Assoc. Executive Director Kaiser Permanente, The Permante Federation Gail WilensyMD Economist, President Defense Health Board, Senior Fellow Project Hope Patrick WilsonCOL Health Care Operations, Office of the Surgeon General and the G-3 for the US Army Medical Command Steve Witz Director Regenstreif Center for H/C Engineering, Purdue University Irving Wladawsky-Berger IBM Academy of Technology, Visiting Professor of Engineering Systems, MIT Tim WolfkillCDR Joint Staff, Chief Medical Plans and strategy Mary Woolley President, Research!America Ed Wyatt Ewyatt Consulting Christine ZanellaPhD Kathmandu University Medical School Howard ZuckerMD Deputy Assistant Secretary Health & Human Services